We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of Efficacy and Safety of Intra-Muscular MgSO<sub>4</sub> with Low Dose Intra-Venous Regimen in Treatment of Eclampsia.
- Authors
Ul Haq, Aqsa Ikram; Naseem, Ulfat; Sadiq, Nadia; Batool, Syeda Maryam; Khalid, Tahira; Bashir, Shama
- Abstract
Introduction: Hypertensive disorders and its complications contribute maximum in maternal morbidity and mortality worldwide especially in developing countries. Multiple drugs have been under trial for a long period of time in means of their efficacy and safety profile. Out of all drugs MgSO4 made its place as one of the treatment of choice in eclamptic patients. It has multiple advantages although its not without side effect, if not used appropriately and with caution. Objective: To compare the efficacy and safety of intramuscular versus low dose intravenous magnesium sulphate in treatment of eclampsia. Study Setting: The study was conducted at Gynecology and Obstetrics Department unit II, Holy Family Hospital, Rawalpindi, from June 20, 2020 to December 20, 2020. Study design was Randomized Controlled Trial. Materials and Methods: Patients were randomly distributed into two groups, group-A (IM Group) and group-B (IV Group). Group-A patients received a loading dose of 4 gm IV MgSO4 over 5-10 minutes+10 gm MgSO4 deep intra-muscular injection (5 gm in each buttock) and a maintenance dose of 5 gm MgSO4 deep intramuscular injection in alternate buttock every 4 hourly. Group-B patients received MgSO4 4 gm slow IV over 5-10 minutes as loading dose and 1 gm MgSO4 per hour as continuous intravenous maintenance infusion. Clinical response to therapy for both drugs was calculated in terms of efficacy and safety. All the data were entered & analyzed by using SPSS v25.0. Both the groups were compared in terms of efficacy and safety by using Chi-Square test. A p-value less than 0.05 were taken as significant. Results: A sample size of 160 eclamptic patients was taken in our study. We divided the patients in two groups: Group A (IM MgSO4) and Group B (IV MgSO4). Group A shows: 45(56.3%) in 18-30 years age group and 35(43.8%) in 31-40 years age group, while in group-B, there were 48(60.0%) in 18-30 years age group and 32(40.0%) in 31-40 years age group. In IM MgSO4 group, prevention from recurrence of seizure was noted in 74(92.5%) and 78(97.5%) in IV MgSO4 group, which is insignificant statistically with a p-value of 0.147. Conclusion: MgSO4 proved itself as one of the best drug for control of convulsions in eclamptic patients. The difference of routes has an effect in means of toxicity which was slightly more in intramuscular route; toxicity was manifested by loss of knee jerk in eclamptic patients. Although there was no profound difference in control of recurrence of seizures in both routes. Keywords: Eclampsia, Intramuscular MgSO4, Intravenous MgSO4.
- Subjects
RAWALPINDI (Pakistan); ECLAMPSIA; DRUG dosage; INTRAMUSCULAR injections; MAGNESIUM sulfate; INTRAVENOUS therapy; AGE groups
- Publication
Journal of Rawalpindi Medical College, 2022, Vol 26, Issue 4, p574
- ISSN
1683-3562
- Publication type
Article
- DOI
10.37939/jrmc.v26i4.1901