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- Title
Post-Traumatic Trigeminal Neuropathy: Neurobiology and Pathophysiology.
- Authors
Eliav, Tal; Benoliel, Rafael; Korczeniewska, Olga A.
- Abstract
Simple Summary: In this article, we provide a review of the current knowledge on trigeminal neuropathy caused of traumatic origin, such as direct nerve damage from dental procedures or motor vehicle accidents. This article focuses on the cellular processes that occur following traumatic nerve damage to the trigeminal nerve, otherwise known as cranial nerve V, that results in chronic pain. Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve injury, there are various mechanisms, including peripheral and central, as well as phenotypic changes and genetic predispositions that may contribute to the development of neuropathic pain. In this article, we review current literature pertaining to the cellular processes that occur following traumatic damage to the trigeminal nerve, also called cranial nerve V, that results in chronic neuropathic pain. We examine the neurobiology and pathophysiology based mostly on pre-clinical animal models of neuropathic/trigeminal pain.
- Subjects
TRIGEMINAL nerve; CRANIAL nerves; TRAFFIC accidents; NEUROPATHY; WOUNDS &; injuries; NEUROBIOLOGY; BLINKING (Physiology)
- Publication
Biology (2079-7737), 2024, Vol 13, Issue 3, p167
- ISSN
2079-7737
- Publication type
Article
- DOI
10.3390/biology13030167