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- Title
Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart.
- Authors
Wei, Li; Xia, Shutao; Li, Yifei; Qi, Yan; Wang, Yue; Zhang, Donghui; Hua, Yimin; Luo, Shuhua
- Abstract
Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be established to achieve multiple functional evaluations by tissue engineering technology. This short review summarized the current advanced applications based on the hIPSC derived heart tissue in molecular mechanisms elucidating and high throughput drug screening.
- Subjects
INDUCED pluripotent stem cells; HIGH throughput screening (Drug development); PLURIPOTENT stem cells; TISSUE engineering
- Publication
Frontiers in Genetics, 2022, Vol 13, p1
- ISSN
1664-8021
- Publication type
Article
- DOI
10.3389/fgene.2022.891159