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- Title
Metastases to the parotid glands: An institutional experience.
- Authors
Calo, Lea; Alboni, Tiziana; Bruno, Carmine; Policardo, Federica; Feraco, Angela; Tralongo, Pietro; Vegni, Federica; Mulè, Antonio; Brigato, Francesca; Rossi, Giorgia; Bussu, Francesco; Pantanowitz, Liron; Galli, Jacopo; Rossi, Esther Diana
- Abstract
Background: Metastatic lesions to the salivary gland are rare and mostly affect the parotids. Metastases represent 8% of all malignant lesions of the parotid gland. Around 80% originate from squamous cell carcinomas (SCC) of the head and neck region. Fine needle aspiration (FNA) plays a crucial role in distinguishing primary salivary gland lesions from metastases. Herein we describe our series of metastases to the parotid glands. Materials and Methods: We analysed 630 parotid gland FNAs over a decade including conventional and liquid‐based cytology specimens. Ancillary techniques such as immunocytochemistry (ICC) were conducted on cell blocks. Results: Eighty (12.4%) cases were malignant lesions, of which 53 (63.75%) were metastases including 24% melanoma, 22.6% SCC, 19% renal carcinomas, 7.5% breast carcinomas, 11.3% lung, 9% intestinal and 1.8% testicular, malignant solitary fibrous tumour and Merkel cell carcinoma. The 53 cases, classified according to the Milan system for salivary cytopathology, belonged to 5 Suspicious for malignancy (SFM) and 48 malignant (M) categories. Forty had a known history of primary malignancy (75.4%), while 13 were suspicious to be a metastatic localisation (24.5%), distributed as 5SFM (2SCC and 3Melanoma) and 8 M. A combination of clinical history, cytomorphology and ICC identified 100% of them. Conclusions: Fine needle aspiration plays a central role in the diagnostic workup of patients with metastatic lesions to their parotid glands, thereby defining the correct management. Diagnostic accuracy may be enhanced by applying ICC. Although melanoma and SCC are the most common histological types, several other malignancies may also metastasize to the parotid glands and should be kept into consideration.
- Subjects
MILAN (Italy); BREAST; PAROTID glands; NEEDLE biopsy; SALIVARY glands; MERKEL cell carcinoma; METASTASIS
- Publication
Cytopathology, 2024, Vol 35, Issue 4, p488
- ISSN
0956-5507
- Publication type
Article
- DOI
10.1111/cyt.13387