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- Title
Early serum (1→3)-β-D-glucan levels in patients with burn injury.
- Authors
Shupp, Jeffrey W.; Petraitiene, Ruta; Jaskille, Amin D.; Pavlovich, Anna R.; Matt, Sarah E.; Nguyen, Do T.; Kath, Melissa A.; Jeng, James C.; Jordan, Marion H.; Finkelman, Malcolm; Walsh, Thomas J.; Shoham, Shmuel
- Abstract
Serum (1→3)-β-D-glucan (BG) is increasingly used as diagnostic marker for invasive fungal infections. Exposure to gauze may lead to false-positive BG assays. The role of BG is unclear in thermally injured patients who frequently require extensive gauze coverage; therefore, we prospectively evaluated BG levels in burn-injured patients. Serum BG levels were measured in 18 burn patients immediately before application of the first dressing and 12 h after. Patients were stratified by extent of total body surface area (TBSA) requiring gauze coverage: <20%, 20-39%, 40-60% and >60%. BG levels were obtained from patients with non-burn trauma as controls. BG results were positive (>80 pg ml−1) in 9/18 (50%) patients at baseline and in 8/18 (44%) 12 h after application of the first dressing. BG levels were positive in 1/5 (20%) of patients with <20% TBSA requiring gauze and in 10/13 (77%) with ≥20% ( P < 0.05). None of the control patients had positive BG at any time point and none of the patients had candidemia at baseline. Mean serum BG levels decreased (19.44 pg ml−1) after gauze placement. False-positive serum BG elevations are common in this patient population. Positivity correlates with extent of TBSA injured, but is not impacted by the gauze itself.
- Subjects
BIOLOGICAL assay; BURNS &; scalds; BLOOD plasma; MYCOSES; SERUM
- Publication
Mycoses, 2012, Vol 55, Issue 3, p224
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/j.1439-0507.2011.02068.x