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- Title
MUCOADHESIVE MICROSPHERES: AN EMINENT ROLE IN CONTROLLED DRUG DELIVERY.
- Authors
Pethe, Devendra B.; Gujarathi, Nayan A.; Rane, Bhushan R.; Pawar, Sunil P.; Bedse, Ajay G.; Chaudhari, Amol R.
- Abstract
Mucoadhesion is simply known as interfacial force interactions between polymeric materials and mucosal tissues. In the last two decades mucoadhesive microspheres have received considerable attention for design of novel drug delivery systems due to their ability to prolong the residence time of dosage forms and to enhance drug bioavailability. Mucoadhesive microspheres have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus layer, controlled and sustained release of drug from dosage form and specific targeting of drugs to the absorption site. Microspheres are the carrier linked drug delivery system in which particle size is ranges from 1-1000 μm range in diameter having a core of drug and entirely outer layers of polymer as coating material.
- Subjects
POLYMER research; TISSUES; MICROSPHERES; DOSAGE forms of drugs; DRUG delivery systems
- Publication
Pharma Science Monitor, 2013, Vol 3, Issue 3, p317
- ISSN
0976-9242
- Publication type
Article