We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
AN OVERVIEW: SUSTAINED RELEASE DRUG DELIVERY TECHNOLOGIES WITH POLYMERIC SYSTEM.
- Authors
Tiwari, Bharat P.; Rane, Bhushan R.; Gujarathi, Nayan A.; Pawar, Sunil P.
- Abstract
In recent years scientific and industrial advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such reputation may be in part accredited to its ease of administration Use of different release retardant for oral sustained release of drugs is a common practice in the pharmaceutical industry. In this study discusses formulation and manufacturing variables affecting the design and performance of the extended-release product by using selected practical examples. Optimal therapy of a disease requires an efficient delivery of active drugs to the tissues, organs that need treatment. Very often doses far in excess to those required in the cells have to be administered in order to achieve the necessary therapeutically effective concentration. This unfortunately may lead to undesirable, toxicological and immunological effects in non-target tissue. A controlled release dosage forms leads to better management of the acute or chronic disease condition. While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category effectively commercialized to date despite Clinical and market demand. The present review addresses formulation, approaches, and a range of technologies with polymeric based sustained drug delivery system.
- Subjects
DRUG delivery systems; ORAL drug administration; ORAL medicine; DOSAGE forms of drugs; PHARMACEUTICAL industry
- Publication
Pharma Science Monitor, 2013, Vol 4, Issue 1, p3506
- ISSN
0976-9242
- Publication type
Article