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- Title
An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation.
- Authors
Park, Seoryeong; Choi, Jaewon; Lee, Yonghee; Noh, Jinsung; Kim, Namphil; Lee, JinAh; Cho, Geummi; Kim, Sujeong; Yoo, Duck Kyun; Kang, Chang Kyung; Choe, Pyoeng Gyun; Kim, Nam Joong; Park, Wan Beom; Kim, Seungtaek; Oh, Myoung-don; Kwon, Sunghoon; Chung, Junho
- Abstract
The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyze their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both ancestral and Omicron receptor-binding domain (RBD) is achieved by a limited number of BCR clonotypes depending on the accumulation of somatic hypermutation (SHM) after the third dose. Our findings suggest that SHM accumulation in the BCR space to broaden its specificity for unseen antigens is a counterprotective mechanism against virus variant immune escape. Repeat vaccination with COVID-19 mRNA vaccines has been shown to increase breadth of the antibody response. Here the authors demonstrate that B cell clones induced by the ancestral COVID-19 vaccine develop into daughter clones with different reactivity to individual SARS-CoV-2 variants through the accumulation of somatic hypermutations.
- Subjects
COVID-19 vaccines; SARS-CoV-2 Omicron variant; SARS-CoV-2; B cells; IMMUNOGLOBULINS; ANTIBODY formation; B cell receptors
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-47743-1