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- Title
Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C.
- Authors
McCafferty, Conor; Cai, Tengyi; Borgel, Delphine; Lasne, Dominique; Renolleau, Sylvain; Vedrenne-Cloquet, Meryl; Bonnet, Damien; Wu, Jemma; Zaw, Thiri; Bhatnagar, Atul; Song, Xiaomin; Van Den Helm, Suelyn; Letunica, Natasha; Attard, Chantal; Karlaftis, Vasiliki; Praporski, Slavica; Ignjatovic, Vera; Monagle, Paul
- Abstract
COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children. While rare, SARS-CoV-2-infected children can develop severe COVID-19 (ARDS) or inflammatory syndrome (MIS-C). Here, the authors use proteomics to characterize hundreds of blood proteins and identify key biological pathways that differentiate MIS-C and ARDS.
- Subjects
MULTISYSTEM inflammatory syndrome in children; COVID-19; ADULT respiratory distress syndrome; BLOOD proteins
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-29951-9