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- Title
Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.
- Authors
Yang, Chen; Hu, Yuzheng; Talishinsky, Aleksandr D.; Potter, Christian T.; Calva, Coleman B.; Ramsey, Leslie A.; Kesner, Andrew J.; Don, Reuben F.; Junn, Sue; Tan, Aaron; Pierce, Anne F.; Nicolas, Céline; Arima, Yosuke; Lee, Seung-Chan; Su, Conghui; Coudriet, Jensine M.; Mejia-Aponte, Carlos A.; Wang, Dong V.; Lu, Hanbing; Yang, Yihong
- Abstract
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity. The prefrontal cortex is involved in goal-directed behaviour. Here the authors show that medial prefrontal cortex activates goal-directed motivation and dopamine neurons via a feedback loop with the anteromedial thalamus.
- Subjects
DOPAMINERGIC neurons; ACTION theory (Psychology); PREFRONTAL cortex; THALAMUS; THALAMIC nuclei; VIDEO excerpts
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-28892-7