We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis.
- Authors
Solam LEE; Young Bin LEE; Sung Jay CHOE; Won-Soo LEE
- Abstract
Treatment of male androgenetic alopecia with 5a-reductase inhibitors is efficacious. However, the risk of adverse sexual effects remains controversial. This systematic review and meta-analysis investigated the risk of adverse sexual effects due to treatment of androgenetic alopecia in male patients with finasteride, 1 mg/day, or dutasteride, 0.5 mg/day. Fifteen randomized double-blinded placebo-controlled trials (4,495 subjects) were meta-analysed. Use of 5a-reductase inhibitors carried a 1.57-fold risk of sexual dysfunction (95% confidence interval (95% CI) 1.19-2.08). The relative risk was 1.66 (95% CI 1.20-2.30) for finasteride and 1.37 (95% CI 0.81-2.32) for dutasteride. Both drugs were associated with an increased risk, although the increase was not statistically significant for dutasteride. As studies into dutasteride were limited, further trials are required. It is important that physicians are aware of, and assess, the possibility of sexual dysfunction in patients treated with 5α-reductase inhibitors.
- Subjects
BALDNESS; FINASTERIDE; META-analysis; ANTIANDROGENS; HAIR diseases
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 1, p12
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3035