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- Title
A review on neurodegenerative disorder -- alzheimer's disease.
- Authors
Bhavani, Keserla; Kuriyakose, Josy; Sindhuja, R.; Chandrashekhar, U. A.; Ashab, A. P.
- Abstract
Alzheimer's disease (AD) is one of the most common problems for old age people. Etiology of AD is not clear, but genetic factors play a major role in determining a person's risk to develop AD. Twin and family studies confirm that AD has a genetic basis. AD genetics has been split into two broad categories: Early onset (EO) and late onset. EO-AD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes such as amyloid precursor protein, presenilin (PSEN)-1, and PSEN-2. Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course, this relation is not complete bit, it is significant. More than 1000 genes studied in relation with AD. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remains unclear. Pathologically, it is characterized by intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contributing to senile plaques. In this review, authors will explain about the different aspects of etiology, pathophysiological mechanisms behind the AD, and its management by conventional drug therapies.
- Subjects
PRESENILINS; ALZHEIMER'S disease; NEUROFIBRILLARY tangles; AMYLOID beta-protein precursor; NEURODEGENERATION; MEDICATION therapy management; AMYLOID plaque
- Publication
Drug Invention Today, 2020, Vol 13, Issue 6, p954
- ISSN
0975-7619
- Publication type
Article