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- Title
Association of MMP8 (-799C/T) (rs11225395) gene polymorphism and chronic periodontitis.
- Authors
Murthykumar, Karthikeyan; Varghese, Sheeja; Priyadharsini, J. Vijayashree
- Abstract
Introduction: The aim of the present study was to analyze the association between MMP8 (-799C/T) gene polymorphism and chronic periodontitis (CP). Materials and Methods: A total of 100 participants were recruited for this study, which included 50 CP and 50 healthy controls. Genomic DNA was extracted from the whole blood collected from the participants. DNA was amplified using specific primers flanking the SfcI region of MMP8 (-799C/T) gene. The amplicon was further subjected to genotyping using restriction fragment length polymorphism (RFLP) using SfcI enzyme. The genotype obtained based on RFLP pattern was recorded and used for statistical analysis. The distribution of genotypes and allele frequencies in the CP and control groups was compared using the Chi-square test. Results: The gene frequency and allele frequency were found to be similar in both groups. Conclusion: The present study denotes that the MMP8 (-799C/T) polymorphism is not associated with CP in the study group analyzed.
- Subjects
GENETIC polymorphisms; SINGLE nucleotide polymorphisms; RESTRICTION fragment length polymorphisms; GENE frequency; PERIODONTITIS
- Publication
Drug Invention Today, 2019, Vol 11, Issue 7, p1594
- ISSN
0975-7619
- Publication type
Article