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- Title
Effect of beta-sitosterol on glucose oxidation in liver of type-2 diabetic rats.
- Authors
Ashritha, M.; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.
- Abstract
Background: Beta-sitosterol which is one of the most common sterols found in plants and some vegetable oils. However, the effect of β-sitosterol on glucose uptake and oxidation in liver is not known. Objectives: The study aimed to identify the effects of beta-sitosterol on 14C-glucose oxidation and 14C-2-deoxyglucose uptake in hepatocytes in high-fat diet and sucrose-induced type-2 diabetic rats. Materials and Methods: β-sitosterol was administered orally to type-2 diabetic rats (20 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and the glucose uptake and oxidation in the liver were analyzed using scintillation counter (β-counter). Results: In type-2 diabetic animals, the 14C-glucose oxidation and 14C-2-deoxyglucose were found to be decreased due to high-fat diet-induced insulin resistance. The β-sitosterol treatment (20 mg/kg b.wt) significantly raised the glucose uptake and oxidation in the liver of type-2 diabetic rats as a result of increased insulin sensitivity mediated increase in insulin-signaling molecules. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol regulates glucose homeostasis through the regulation of glucose uptake and oxidation as a result of increase in the insulin sensitivity in liver of type-2 diabetic rats.
- Subjects
OXIDATION of glucose; STREPTOZOTOCIN; CATABOLITE repression; SCINTILLATION counters; LIVER; INSULIN resistance
- Publication
Drug Invention Today, 2019, Vol 12, Issue 6, p1272
- ISSN
0975-7619
- Publication type
Article