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- Title
非小细胞肺癌相关lncRNA的研究进展.
- Authors
张亚琛; 梁迪; 靳晶; 刘聪敏; 贺宇彤
- Abstract
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation, differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therapy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurrence, diagnosis, therapy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.
- Subjects
LUNG cancer prevention; RNA physiology; LUNG cancer prognosis; CELL proliferation; APOPTOSIS; CELL differentiation; GENE expression; LUNG tumors; DISEASE management; EARLY diagnosis; MEDICAL coding; EPIGENOMICS
- Publication
Chinese Journal of Lung Cancer, 2018, Vol 21, Issue 1, p43
- ISSN
1009-3419
- Publication type
Article
- DOI
10.3779/j.issn.1009-3419.2018.01.06