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- Title
Clinical role of F-18 FDG PET/CT in Differentiating Malignant and Benign Pleural Effusion in Patients with Lung Cancer.
- Authors
Riqiang Liao; Xuening Yang; Siyun Wang; Qing Zhou; Qiang Nie; Wenzhao Zhong; Song Dong; Yilong Wu
- Abstract
Background and objective: Pleural effusions, a common feature among patients with lung cancer, should be differentiated into benign or malignant pleural effusions. F-18 fluorodeoxyglucose positron emission tomography/ computed tomography (PET/CT) is one of accurate diagnostic tool for differentiating benign from malignant disease and for mediastinal lymph node staging. We explored the clinical role of PET/CT for differentiating malignant pleural effusion from benign pleural effusion among patients with lung cancer. Methods: We retrospectively reviewed the data from all patients with lung cancer and pleural effusion who underwent F-18 FDG PET/CT. The PET/CT results were compared with the pathologic diagnosis or clinical follow-up. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET/CT for detecting malignant pleural metastases were calculated. Results: A total of 33 patients were enrolled. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET/CT were 81.5%, 83.3%, 95.7%, 50.0%, and 81.8%, respectively, for detecting malignant pleural effusions lung cancer patients. Conclusion: Our results suggest that F-18 FDG PET/CT can play a significant role in diagnosing lung cancer patients with pleural diffusions, with low false-positive rate. However, negative findings under PET/CT should be confirmed through further tests.
- Subjects
DIAGNOSIS of cancer in the pleura; CANCER patients; DEOXY sugars; DIFFERENTIAL diagnosis; LUNG tumors; PLEURAL effusions; RADIOPHARMACEUTICALS; TOMOGRAPHY; POSITRON emission tomography; PREDICTIVE tests; RETROSPECTIVE studies; DISEASE complications; DIAGNOSIS
- Publication
Chinese Journal of Lung Cancer, 2012, Vol 15, Issue 11, p652
- ISSN
1009-3419
- Publication type
Article
- DOI
10.3779/j.issn.1009-3419.2012.11.08