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- Title
Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022.
- Authors
Ren, Yu-ting; Tian, Hong-pan; Xu, Jia-le; Liu, Man-qing; Cai, Kun; Chen, Shu-liang; Ni, Xue-bing; Li, Yi-rong; Hou, Wei; Chen, Liang-jun
- Abstract
Severe fever with thrombocytopenia syndrome virus (SFTSV), an etiological agent causing febrile human disease was identified as an emerging tick-borne bunyavirus. The clinical disease characteristics and case fatality rates of SFTSV may vary across distinct regions and among different variant genotypes. From 2018 to 2022, we surveyed and recruited 202 severe fever with thrombocytopenia syndrome (SFTS) patients in Hubei Province, a high-incidence area of the epidemic, and conducted timely and systematic research on the disease characteristics, SFTSV diversity, and the correlation between virus genome variation and clinical diseases. Our study identified at least 6 genotypes of SFTSV prevalent in Hubei Province based on the analysis of the S, M, and L genome sequences of 88 virus strains. Strikingly, the dominant genotype of SFTSV was found to change during the years, indicating a dynamic shift in viral genetic diversity in the region. Phylogenetic analysis revealed the genetic exchange of Hubei SFTSV strains was relatively frequent, including 3 reassortment strains and 8 recombination strains. Despite the limited sample size, SFTSV C1 genotype may be associated with higher mortality compared to the other four genotypes, and the serum amyloid A (SAA) level, an inflammatory biomarker, was significantly elevated in these patients. Overall, our data summarize the disease characteristics of SFTSV in Hubei Province, highlight the profound changes in viral genetic diversity, and indicate the need for in-depth monitoring and exploration of the relationship between viral mutations and disease severity. Author summary: Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus, caused febrile human disease. Studies have shown that the virus was constantly mutating, and the clinical features of distinct mutational genotypes were also different. Therefore, routine surveillance of this disease's epidemic features is necessary, especially in high-incidence areas. In this study, we conducted timely and systematic research on the disease characteristics, SFTSV diversity, and the correlation between virus genome variation and clinical diseases based on 202 severe fevers with thrombocytopenia syndrome (SFTS) patients in Hubei Province, from 2018 to 2022. Our findings identified at least six prevalent genotypes of SFTSV in Hubei Province and revealed that the dominant genotype of the virus changed over time, indicating a complex genotype diversity of Hubei SFTSV strains. Frequent genetic exchange was also revealed by phylogenetic analysis involving 3 reassortment strains and 8 recombination strains. Despite the limited sample size, SFTSV C1 genotype may be relevant to higher mortality with significant augment level of inflammatory marker serum amyloid A (SAA) than other four genotypes. This study updated the disease characteristics of SFTS with SFTSV epidemic diversity in Hubei Province and provided important insights into the relationship between viral mutations and disease severity.
- Subjects
HUBEI Sheng (China); GENETIC variation; VIRAL variation; VIRAL mutation; THROMBOCYTOPENIA; BIOMARKERS; LYME disease
- Publication
PLoS Neglected Tropical Diseases, 2023, Vol 17, Issue 9, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0011654