We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women.
- Authors
Alvarez‐Arcaya; Combarros, O.; Llorca, J.; Sánchez‐Guerra, M.; Berciano, J.; Fernández‐Viadero, C.; Peña, N.
- Abstract
Introduction – Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE) gene may act in synergism with the ε4 allele of apolipoprotein E (APOE) to increase the risk of Alzheimer's disease (AD), but this is controversial. Material and methods – We genotyped for the BCHE‐K and APOE ε4 alleles in a sample of 249 AD patients and 250 controls derived from the same region in a Spanish population. Results – A protective effect of the K variant of BCHE with an odds ratio of 0.41 (95% confidence interval 0.19–0.86, P=0.02) was observed among non‐APOE ε4 carriers, but it was limited to women. Conclusion – Our study is the first to demonstrate that lower susceptibility to AD determined by the K variant of BCHE is dependent on gender.
- Subjects
ALZHEIMER'S disease risk factors; PRESENILE dementia; DISEASE risk factors
- Publication
Acta Neurologica Scandinavica, 2000, Vol 102, Issue 6, p350
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1034/j.1600-0404.2000.102006350.x