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- Title
Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time.
- Authors
Chen, Wei J.; Pi-Hua Liu; Yen-Yi Ho; Kuo-Liong Chien; Min-Tzu Lo; Wei-Liang Shih; Yu-Chun Yen; Wen-Chung Lee
- Abstract
Background: The purpose of this study was to estimate both cross-sectional sibling recurrence risk ratio (λs) and lifetime λs for the metabolic syndrome and its individual components over time among sibships in the prospectively followed-up cohorts provided by the Genetic Analysis Workshop 13. Five measures included in the operational criteria of the metabolic syndrome by the Adult Treatment Panel III were examined. A method for estimating sibling recurrence risk with correction for complete ascertainment was used to estimate the numerator, and the prevalence in the whole cohort was used as the denominator of λs. Results: Considerable variability in the λs was found in terms of different time-points for the cross-sectional definition, the times of fulfilling the criterion for lifetime definition, and different components. Obesity and hyperglycemia had the highest cross-sectional λs of the five components. Both components also had the largest slopes in the linear trend of the lifetime λs. However, the magnitudes of the lifetime λs were similar to that of the mean cross-sectional λs, which were <2. The results of nonparametric linkage analysis showed only suggestive evidence of linkage between one marker and lifetime diagnosis of low high-density lipoprotein cholesterol and metabolic syndrome, respectively. Conclusion: The λs of the metabolic syndrome and its components varies substantially across time, and the λs of lifetime diagnosis was not necessarily larger than that of a cross-sectional diagnosis. The magnitude of λs does not predict well the maximum LOD score of linkage analysis.
- Subjects
METABOLIC syndrome; HIGH density lipoproteins; LOW density lipoproteins; CHOLESTEROL; LINKAGE (Genetics)
- Publication
BMC Genetics, 2003, Vol 4, pS33
- ISSN
1471-2156
- Publication type
Article
- DOI
10.1186/1471-2156-4-S1-S33