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- Title
Neurotoxicity, antipsychotic and antidepressant screening of the fruit of Rosa moschata in mice.
- Authors
Jamal, Muhammad; Rehman, Mujeebur; Nabi, Muhammad; Khattak, Zenat Fatima; Awan, Abdul Aleem; Shah, Mudassir; Ali, Niaz; Hussain, Iftekhar; Sherkheli, Muhammad Azhar; Haq, Rizwanul
- Abstract
Extract of Rosa moschata (RM) fruits was evaluated for the anti-schizophrenic and antidepressant activities. We first determined the neurotoxic effect of hydro-methanolic extract of RM using inverted-screen test. Further, the extract was tested in the ketamine-induced schizophrenia model and its antidepressant effect was assessed by tail suspension and forced swim test in mice. Different doses of extract were administered once/day to the animals for 14 consecutive days. Behavioral parameters were investigated 24h after last administration of drug/extract by performing Ymaze test, forced swim test and open field test. Results showed that TD50 of the extract was ~1000mg/Kg. Moreover, extract significantly increased % alternations in YMT, reduced immobility time in FST and enhanced locomotion in OFT compared to saline group. Similarly, RM extract decreased time of immobility in FST and TST significantly showed antidepressant effect. Thus, it was concluded that extract of RM has antipsychotic and antidepressant properties.
- Subjects
ANTIDEPRESSANTS; NEUROTOXICOLOGY; DRUG administration; FRUIT; MICE; DYNAMOMETER
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2023, Vol 36, Issue 3, p793
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2023.36.3.REG.793-799.1