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- Title
Silymarin Inhibits Proliferation and Induces Apoptosis in Epstein-Barr Virus-Positive Lymphoma Cells by Suppressing Nuclear Factor-Kappa B Pathway.
- Authors
Suli Lu; Jun Zhang; Yue Wang
- Abstract
Epstein Barr virus-positive lymphoma results from the loss of homeostatic balance between Epstein Barr virus and immune cells. In this study, we investigated the mechanism underlying reduction in Epstein Barr virus-positive lymphoma cell proliferation and apoptosis by silymarin, an anti-inflammatory/antioxidant molecule extracted from Silybum marianum (milk thistle). We examined the effect of silymarin on Raji cell proliferation, apoptosis, the expression of latent membrane protein 1, the proteins related to apoptosis, and the activation of nuclear factor kappa-B. Results showed that silymarin inhibited the proliferation and promoted apoptosis of Raji cells in a concentration-dependent manner. Also, silymarin reduced phosphorylated inhibitor of nuclear factor kappa-B and p65 levels. Silymarin treatment elevated latent membrane protein 1 expression and knockdown of this protein led to increased proliferation inhibition and apoptosis by silymarin. In conclusion, nuclear factor kappa-B and latent membrane protein 1 knockdown could work in concert with silymarin in suppressing Epstein Barr virus-positive lymphoma cell proliferation and inducing apoptosis.
- Subjects
ANTINEOPLASTIC agents; APOPTOSIS; CANCER patients; CELL lines; CELLULAR immunity; CELLULAR signal transduction; EPSTEIN-Barr virus diseases; FLAVONOIDS; HOMEOSTASIS; LYMPHOMAS; DNA-binding proteins; PLANT extracts; TREATMENT effectiveness; PHARMACODYNAMICS
- Publication
Current Topics in Nutraceutical Research, 2020, Vol 18, Issue 4, p348
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.18:348–353