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- Title
Serum activity/concentration profiles of a sustained-released formulation of sulphathiazole-trimethoprim (2-5:1) in calves.
- Authors
Sumano, H.; Gutierrez, L.; Zamora, M. A.; Perez, M.; Cruz, C.
- Abstract
Thirty-six two-week-old healthy Holstein-Friesian calves weighing between 52 and 58 kg were divided at random into three groups of 12; group A calves were given a single oral bolus containing 2.5 g sulphathiazole and 1 g trimethoprim in a sustained-release formulation; group B received the same doses of the drugs but the trimethuprim was not in a sustained-release formulation; group C received a bolus containing 2.5 g sulphathiazole and 0.5 g conventional trimethoprim. Blood samples were collected at intervals for two days, the serum was separated and the composite antibacterial activity profiles of the mixture were analysed by an agar-diffusion microbiological method. The mean maximum activities in the serum of the three groups were 23.4 μg/ml in group A, 9.25 μg/ml in group B and 8.01 μg/ml in group C. The mean areas under the curves of the serum activity time curves were 838 μg/ml/hour in group A, 216 μg/ml,/hour in group B and 182 μg/ml/hour in group C.
- Subjects
DRUG dosage; ANTIBACTERIAL agents; HOLSTEIN-Friesian cattle; SERUM; MICROBIOLOGY
- Publication
Veterinary Record: Journal of the British Veterinary Association, 2004, Vol 155, Issue 21, p672
- ISSN
0042-4900
- Publication type
Article
- DOI
10.1136/vr.155.21.672