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- Title
Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer.
- Authors
Yamashita, Kaoru; Ohara, Masaru; Kojima, Taro; Nishimura, Rumi; Ogawa, Tetsuji; Hino, Takamune; Okada, Mitsugi; Toratani, Shigeaki; Kamata, Nobuyuki; Sugai, Motoyuki; Sugiyama, Masaru
- Abstract
Drug-resistant opportunistic infections may cause health problems in immunocompromised hosts. Representative microorganisms in opportu-nistic infections of the oral cavity are Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. We investigated the prevalence of drug-resistant opportunistic microorganisms in elderly adults receiving follow-up examinations after primary treatment of oral cancer. Oral microor-ganisms were collected from patients satisfactorily treated for oral cancer (defined as good outcomes to date) and a group of healthy adults (controls). After identification of microorganisms, the prevalence of drug-resistant microorganisms was studied. Pulsed-field gel electrophoresis (PFGE) and staphylococcal cassette chromosome mee (SCCmec) typing were also performed for methicillin-resistant S aureus (MRSA). Statistical analysis revealed no significant differ-ences in the prevalences of the three microorganisms between the groups. Surprisingly, 69.2% of 5 aureus isolates showed oxacillin resistance, suggesting that MRSA colonization is increasing among older Japa-nese. These MRSA isolates possessed SCCmec types II and IV but no representative toxin genes. Our results indicate that a basic infection control strategy, including standard precautions against MRSA, is important for elderly adults, particularly after treat-ment for oral cancer.
- Subjects
DRUG resistance; OPPORTUNISTIC infections; TREATMENT of dental caries; PULSED-field gel electrophoresis; STAPHYLOCOCCUS aureus; PSEUDOMONAS aeruginosa
- Publication
Journal of Oral Science, 2013, Vol 55, Issue 2, p145
- ISSN
1343-4934
- Publication type
Article
- DOI
10.2334/josnusd.55.145