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- Title
Gene Therapy in Cancer Treatment: Why Go Nano?
- Authors
Roma-Rodrigues, Catarina; Rivas-García, Lorenzo; Baptista, Pedro V.; Fernandes, Alexandra R.
- Abstract
The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications.
- Subjects
GENE therapy; CANCER genes; CANCER treatment; EXOSOMES; GENOME editing; GENE silencing; RNA interference
- Publication
Pharmaceutics, 2020, Vol 12, Issue 3, p233
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics12030233