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- Title
Neoadjuvant chemotherapy in technically unresectable carcinoma of external auditory canal.
- Authors
Joshi, Amit; Tandon, Nidhi; Noronha, Vanita; Dhumal, Sachin; Patil, Vijay; Arya, Supreeta; Juvekar, Shashikant; Agarwal, Jaiprakash; Cruz, Anil D.; Pai, Prathmesh; Prabhash, Kumar
- Abstract
Background: Carcinoma of external auditory canal (EAC) is a very rare malignancy with surgical resection as the main modality of treatment. The outcomes with nonsurgical modalities are very dismal. We present a retrospective analysis of 4 patients evaluating the role of neoadjuvant chemotherapy in technically unresectable cancers. Materials and Methods:This is a retrospective analysis of 4 patients from our institute from 2010 to 2014 with carcinoma EAC who were deemed unfi t for surgery due to extensive disease involving occipital bone with soft tissue infi ltration (n = 2), temporal dura (n = 1), left temporal lobe, and extensive soft tissue involvement (n = 1). All these patients received neoadjuvant chemotherapy with docetaxel, cisplatin and 5 fl uorouracil (n = 3) and paclitaxel and cisplatin (n = 1). Results: Response evaluation showed a partial response (PR) in 3 and stable disease (SD) in 1 patient by Response Evaluation Criteria in Solid Tumors criteria. All 3 patients who received 3 drug chemotherapy had PR while 1 patient who received 2 drug chemotherapy had SD. Two of these patients underwent surgery, and other 2 underwent defi nitive chemoradiation. One of 3 patients who achieved PR underwent surgical resection; the other 2 remained unresectable in view of the persistent intradural extension and infratemporal fossa involvement. One patient who had SD could undergo surgery in view of clearance of infraatemporal fossa. Recent follow-up shows that 3 out of these 4 patients are alive. Conclusion: This indicates that there may be a role of induction chemotherapy in converting potentially unresectable tumors to resectable disease that could produce better outcomes in carcinoma EAC.
- Subjects
CANCER chemotherapy; EAR canal; ADJUVANT treatment of cancer; DOCETAXEL; CISPLATIN; PACLITAXEL; FLUOROURACIL; MAGNETIC resonance imaging; CANCER
- Publication
Indian Journal of Medical & Paediatric Oncology, 2015, Vol 36, Issue 3, p172
- ISSN
0971-5851
- Publication type
Article
- DOI
10.4103/0971-5851.166734