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- Title
Obesity increases allergic airway inflammation that can be successfully treated by oral tolerance.
- Authors
Geissler, Nora; Orola, Maria; Alinaghi, Masoumeh; Nardo, Alexander; Stulnig, Thomas M.; Séneca, Joana; Schmid, Anna; Korb, Elke; Svoboda, Tatjana; Garner‐Spitzer, Erika; Kundi, Michael; Ehling‐Schulz, Monika; Schabussova, Irma; Inic‐Kanada, Aleksandra; Wiedermann, Ursula
- Abstract
This article explores the potential link between obesity and respiratory allergies. The study conducted on mice found that obesity exacerbates the allergic response, leading to heightened manifestations compared to lean mice. However, the researchers also discovered that oral tolerance induction can effectively attenuate the allergic response and lung inflammation in obese mice. The findings suggest that mucosal allergen-specific immunomodulation may function by reducing specific inflammatory markers and maintaining certain immune cells in the lungs.
- Subjects
LEPTIN; OVALBUMINS; TREATMENT effectiveness; OBESITY; GREEN light; NON-communicable diseases; ALVEOLAR macrophages
- Publication
Allergy, 2024, Vol 79, Issue 2, p529
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15989