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- Title
The bursa of Fabricius: a trapping site for environmental antigens.
- Authors
Ekino, S.; Suginohara, K.; Urano, T.; Fujii, H.; Matsuno, K.; Kotani, M.
- Abstract
The entry of environmental antigens into the lumen of the bursa of Fabricius was prevented by ligating the bursal duct prior to hatching (BDL: bursal duct ligation). The development of `natural' serum agglutinins for bacteria and heteroerythrocytes was markedly suppressed by BDL. The antigen-specific recovery was observed by simultaneous administration of sterile antigens into the bursal lumen at the time of BDL. These results strongly suggest that the bursa of Fabricius is a major channel through which environmental antigens stimulate the immune system and induce the formation of `natural' serum agglutinins.
- Subjects
BURSA fabricii; ANTIGENS; SERUM; AGGLUTININS; IMMUNE system; CHICKENS
- Publication
Immunology, 1985, Vol 55, Issue 3, p405
- ISSN
0019-2805
- Publication type
Article