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- Title
DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory.
- Authors
Marshall, Paul R.; Davies, Joshua; Qiongyi Zhao; Wei-Siang Liau; Yujin Lee; Basic, Dean; Periyakaruppiah, Ambika; Zajaczkowski, Esmi L.; Leighton, Laura J.; Madugalle, Sachithrani U.; Musgrove, Mason; Kielar, Marcin; Brueckner, Arie Maeve; Hao Gong; Haobin Ren; Walsh, Alexander; Kaczmarczyk, Lech; Jackson, Walker S.; Chen, Alon; Spitale, Robert C.
- Abstract
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation. One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.
- Subjects
GENETIC regulation; DNA structure; GENE silencing; DNA; MEMORY
- Publication
Journal of Neuroscience, 2024, Vol 44, Issue 15, p1
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0093-23.2024