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- Title
Combination Stem Cell Therapy for the Treatment of Severe Limb Ischemia: Safety and Efficacy Analysis.
- Authors
Lasala, Gabriel P.; Silva, Jose A.; Gardner, Philip A.; Minguell, Jose J.
- Abstract
The infusion of a source of endothelial progenitors (EPCs) to limb ischemia (LB) patients has been used to increase angiogenesis. Because the formation of new blood vessels involves, in addition to EPCs, other cells and angiogenic regulators, we postulate that a combination cell therapy including EPCs and mesenchymal stem cells (a source of pericytes progenitors and angiogenic regulators) may represent a preferential stimuli for the development of blood vessels. In this phase I clinical trial, patients with LI were infused with a cell product consisting of autologous bone marrow-derived mononuclear and mesenchymal stem cells. After 10 ± 2 months of follow-up, efficacy assessment demonstrated improvements in walking time, ankle brachial pressure, and quality of life. Concomitantly, angiographic and 99mTc-TF perfusion scintigraphy scores confirmed increased perfusion in the treated limbs. These results show that the use of a combination cell therapy is safe, feasible, and appears effective in patients with LI.
- Subjects
HEALTH outcome assessment; STEM cell research; ISCHEMIA treatment; BLOOD circulation disorders; NEOVASCULARIZATION
- Publication
Angiology, 2010, Vol 61, Issue 6, p551
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319710364213