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- Title
Effects of Cilostazol and Pentoxifylline on Forearm Reactive Hyperemia Response, Lipid Profile, Oxidative Stress, and Inflammatory Markers in Patients With Intermittent Claudication.
- Authors
de Albuquerque, Renato Maranhão; Virgini-Magalhães, Carlos Eduardo; Sicuro, Fernando Lencastre; Bottino, Daniel Alexandre; Bouskela, Eliete
- Abstract
Peripheral arterial disease may lead to lower limb claudication and increased risk of systemic vascular dysfunction. In this article, the authors have investigated the peripheral vascular dysfunction evaluating forearm blood flow using venous occlusion plethysmography, lipid profile, and C-reactive protein in 60 patients with moderate intermittent claudication treated during 20 weeks with placebo (n = 16), cilostazol (200 mg/d; n = 17), or pentoxifylline (1200 mg/d; n = 15) in a randomized double-blinded clinical trial, taking into account smoking. Forearm blood flow after reactive hyperemia response (FBFh) or oral nitroglycerine spray to evaluate endothelial-dependent and endothelial-independent vasodilation, respectively, pain-free and maximal walking distance, levels of C-reactive protein, triglycerides, cholesterol, low-density lipoprotein, and high-density lipoprotein-cholesterol in plasma were determined. The results showed that there was an improvement in the high-density lipoprotein-cholesterol, pain-free and maximal walking distance, and FBFh independent of treatment in nonsmoking patients. Cilostazol increased high-density lipoprotein-cholesterol level, maximal walking distance, and FBFh, whereas pentoxifylline reduced C-reactive protein level and increased maximal walking distance in total and nonsmoking groups. No treatment was effective in smokers.
- Subjects
VASCULAR diseases; PLETHYSMOGRAPHY; INTERMITTENT claudication; ISOPENTENOIDS; ANTI-inflammatory agents; PENTOXIFYLLINE
- Publication
Angiology, 2008, Vol 59, Issue 5, p549
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319707309656