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- Title
Silica-induced Precipitation of Calcium Phosphate in the Presence of Inhibitors of Hydroxyapatite Formation.
- Authors
DAMEN, J. J. M.; TEN CATE, J. M.
- Abstract
The promotion and the inhibition of hydroxyapatite formation by various substances were determined by measurement of the induction time of spontaneous precipitation (ti) from supersaturated solutions. Silica was found to decrease t. in Hepes-buffered (pH 7.2) supersaturated solutions with a wide range of calcium-to-phosphate ratios and concentrations. Also, in suspensions of the oral bacteria S. mutans or C. matruchotii in 1 mmol/L calcium, 7.5 mmol/ L phosphate, and 50 mmol/L Hepes (pH 7.2), silica was capable of stimulating precipitation. Macromolecules derived from these bacteria by freezing and thawing appeared to be strong inhibitors of calcium phosphate precipitation. In the presence of silica, the effects of these bacterial inhibitors could be partially overcome, which supports the idea that silica in dental plaque is a promoter of calculus formation. In contrast, inhibition of calcium phosphate precipitation by a low-molecular-weight inhibitor, pyrophosphate, could not be counteracted by silica.
- Subjects
CALCIUM phosphate; SILICA; HYDROXYAPATITE; SUPERSATURATED solutions; CHEMICAL inhibitors; PYROPHOSPHATES
- Publication
Journal of Dental Research, 1992, Vol 71, Issue 3, p453
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/00220345920710030601