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- Title
Roles of Twist1 in lipid and glucose metabolism.
- Authors
Huang, Liuyifei; Xing, Yan; Ning, Xiaoxuan; Yu, Zhixiang; Bai, Xiao; Liu, Limin; Sun, Shiren
- Abstract
The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcriptional factor Twist1 has been associated with not only the embryonic development, cancer, and fibrotic diseases, but also the regulation of lipid and glucose metabolism. In this review, we will discuss the roles and mechanisms of Twist1 in the obesity-associated white adipose tissue inflammation and insulin resistance, brown adipose tissue metabolism, fatty acid oxidation, and glucose metabolism in skeletal muscle to provide a rational perspective to consider Twist1 as a potential treatment target in clinic. Epq8RQY38Fsn9qua6D8Y77 Video Abstract
- Subjects
LIPID metabolism; GLUCOSE metabolism; ADIPOSE tissue physiology; TISSUE metabolism; WHITE adipose tissue; BROWN adipose tissue; INSULIN
- Publication
Cell Communication & Signaling, 2023, Vol 21, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-023-01262-6