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- Title
Transplacental supply of mannose and inositol in uncomplicated pregnancies using stable isotopes.
- Authors
Staat BC; Galan HL; Harwood JE; Lee G; Marconi AM; Paolini CL; Cheung A; Battaglia FC; Staat, Barton C; Galan, Henry L; Harwood, Jeri E F; Lee, Gene; Marconi, Anna Maria; Paolini, Cinzia L; Cheung, Alex; Battaglia, Frederick C
- Abstract
<bold>Objective: </bold>The aim of this study was to determine relative contributions of transplacental flux vs. fetal production for inositol and mannose in normal term pregnancies.<bold>Study Design: </bold>Seven term uncomplicated pregnancies undergoing cesarean section were infused with (13)C- and (2)H-labeled isotopes of glucose, inositol, and mannose until a steady state was achieved. Maternal and fetal concentrations of labeled and unlabeled glucose, mannose, and inositol were measured using gas chromatography/mass spectroscopy. The fetomaternal molar percentage excess ratio was calculated for each glucose, mannose, and inositol.<bold>Results: </bold>The fetomaternal molar percentage excess ratio of mannose in the fetal artery (F(artery)/M) was 0.99 [97.5% confidence interval (CI), 0.91-1.07] and in the fetal vein (F(vein)/M), 1.02 (97.5% CI, 0.95-1.10). Both were not significantly different from 1.0, consistent with transplacental supply. The fetomaternal ratios for glucose were similar to mannose (fetal artery, 0.95; 97.5% CI, 0.84-1.15; and fetal vein, 0.96; 97.5% CI, 0.85-1.07). The fetomaternal ratio for inositol was significantly less than 1.0 (fetal artery, 0.08; 97.5% CI, 0.05-0.12; fetal vein, 0.12; 97.5% CI, 0.06-0.18), indicating little transplacental flux and significant fetal production.<bold>Conclusion: </bold>In normal term pregnancies, fetal mannose and glucose concentrations are dependent upon maternal transplacental supply. Fetal inositol is not dependent upon transplacental supply.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2012, Vol 97, Issue 7, p2497
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2011-1800