We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Syntheses, Characterization, Crystal Structures and Xanthine Oxidase Inhibitory Activity of Hydrazones.
- Authors
Xiao-Jun Zhao; Ling-Wei Xue; Qiao-Ru Liu
- Abstract
Four new fluoro-containing hydrazones were synthesized from 4-fluorobenzaldehyde with chloro- and nitro-substituted benzohydrazides. They are 3-chloro-N'-(4-fluorobenzylidene)benzohydrazide (1), 2-chloro-N'-(4-fluorobenzylidene) benzohydrazide (2), N'-(4-fluorobenzylidene)-4-nitrobenzohydrazide (3), and N'-(4-fluorobenzylidene)-3-nitrobenzohydrazide (4). The compounds have been characterized by IR and 1H NMR spectroscopy, as well as X-ray single crystal determination. Xanthine oxidase (XO) inhibitory activity indicated that the nitro substituted compounds 3 and 4 have effective activity. Docking simulation was performed to insert the compounds into the crystal structure of xanthine oxidase at the active site to investigate the probable binding modes.
- Subjects
XANTHINE oxidase; CRYSTAL structure; NUCLEAR magnetic resonance spectroscopy; NITRO compounds; HYDRAZONE derivatives; SINGLE crystals; HYDRAZONES
- Publication
Acta Chimica Slovenica, 2023, Vol 70, Issue 4, p524
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2023.8370