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- Title
Reclassification of Treatment Strategy with Fractional Flow Reserve in Cancer Patients with Coronary Artery Disease.
- Authors
Kim, Jin Wan; Dayah, Tariq J.; Javaid, Awad; Monlezun, Dominique J.; Balanescu, Dinu V.; Donisan, Teodora; Karimzad, Kaveh; Hakeem, Abdul; Boone, David L.; Palaskas, Nicolas; Lopez-Mattei, Juan; Kim, Peter Y.; Durand, Jean-Bernard; Song, Juhee; Balanescu, Serban M.; Yang, Eric H.; Herrmann, Joerg; Marmagkiolis, Konstantinos; Toutouzas, Konstantinos; Johnson, Nils P.
- Abstract
Background and Objectives: Cancer and coronary artery disease (CAD) often coexist. Compared to quantitative coronary angiography (QCA), fractional flow reserve (FFR) has emerged as a more reliable method of identifying significant coronary stenoses. We aimed to assess the specific management, safety and outcomes of FFR-guided percutaneous coronary intervention (PCI) in cancer patients with stable CAD. Materials and Methods: FFR was used to assess cancer patients that underwent coronary angiography for stable CAD between September 2008 and May 2016, and were found to have ≥50% stenosis by QCA. Patients with lesions with an FFR > 0.75 received medical therapy alone, while those with FFR ≤ 0.75 were revascularized. Procedure-related complications, all-cause mortality, nonfatal myocardial infarction, or urgent revascularizations were analyzed. Results: Fifty-seven patients with stable CAD underwent FFR on 57 lesions. Out of 31 patients with ≥70% stenosis as measured by QCA, 14 (45.1%) had an FFR ≥ 0.75 and lesions were reclassified as moderate and did not receive PCI nor DAPT. Out of 26 patients with <70% stenosis as measured by QCA, 6 (23%) had an FFR < 0.75 and were reclassified as severe and were treated with PCI and associated DAPT. No periprocedural complications, urgent revascularization, acute coronary syndromes, or cardiovascular deaths were noted. There was a 22.8% mortality at 1 year, all cancer related. Patients who received a stent by FFR assessment showed a significant association with decreased risk of all-cause death (HR: 0.37, 95% CI 0.15–0.90, p = 0.03). Conclusions: Further studies are needed to define the optimal therapeutic approach for cancer patients with CAD. Using an FFR cut-off point of 0.75 to guide PCI translates into fewer interventions and can facilitate cancer care. There was an overall reduction in mortality in patients that received a stent, suggesting increased resilience to cancer therapy and progression.
- Subjects
CORONARY artery disease; CANCER patients; PERCUTANEOUS coronary intervention; CORONARY angiography; ACUTE coronary syndrome; DRUG-eluting stents
- Publication
Medicina (1010660X), 2022, Vol 58, Issue 7, pN.PAG
- ISSN
1010-660X
- Publication type
Article
- DOI
10.3390/medicina58070884