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- Title
Protein tyrosine phosphatases: regulatory mechanisms.
- Authors
Hertog, Jeroen den; Östman, Arne; Böhmer, Frank-D.
- Abstract
Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
- Subjects
PROTEIN-tyrosine phosphatase; CELLS; PROTEOLYSIS; LIGANDS (Biochemistry); BINDING sites; CATALYSIS
- Publication
FEBS Journal, 2008, Vol 275, Issue 5, p831
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2008.06247.x