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- Title
A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level.
- Authors
Diederich, Sandra; Babiuk, Shawn; Boshra, Hani
- Abstract
Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra viruses) are highly virulent, as well as zoonotic, and are thus classified as BSL4 pathogens. Although only 5 members of this genus have been isolated and characterized, metagenomics analysis using animal fluids and tissues has demonstrated the existence of other novel henipaviruses, suggesting a far greater degree of phylogenetic diversity than is currently known. Using a variety of molecular biology techniques, it has been shown that these viruses exhibit varying degrees of tropism on a species, organ/tissue, and cellular level. This review will attempt to provide a general overview of our current understanding of henipaviruses, with a particular emphasis on viral tropism.
- Subjects
VIRAL tropism; HENIPAVIRUSES; MOLECULAR biology; TROPISMS; SPECIES; RNA viruses
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 10, p2048
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15102048