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- Title
Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles.
- Authors
Bittner, Elena; Stehlik, Thorsten; Lam, Jason; Dimitrov, Lazar; Heimerl, Thomas; Schöck, Isabelle; Harberding, Jannik; Dornes, Anita; Heymons, Nikola; Bange, Gert; Schuldiner, Maya; Zalckvar, Einat; Bölker, Michael; Schekman, Randy; Freitag, Johannes
- Abstract
Peroxisomes are organelles with crucial functions in oxidative metabolism. To correctly target to peroxisomes, proteins require specialized targeting signals. A mystery in the field is the sorting of proteins that carry a targeting signal for peroxisomes and as well as for other organelles, such as mitochondria or the endoplasmic reticulum (ER). Exploring several of these proteins in fungal model systems, we observed that they can act as tethers bridging organelles together to create contact sites. We show that in Saccharomyces cerevisiae this mode of tethering involves the peroxisome import machinery, the ER–mitochondria encounter structure (ERMES) at mitochondria and the guided entry of tail-anchored proteins (GET) pathway at the ER. Our findings introduce a previously unexplored concept of how dual affinity proteins can regulate organelle attachment and communication. Proteins require targeting signals to reach their destination. This study reveals that dual affinity proteins which possess targeting signals for different organelles can act as dynamic tether proteins that bridge organelles together to create contact sites.
- Subjects
PEROXISOMES; FUNGAL proteins; ENDOPLASMIC reticulum; PROTEINS; PROTEIN models; ORGANELLES; GOLGI apparatus
- Publication
PLoS Biology, 2024, Vol 22, Issue 2, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.3002508