We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Stereoarrayed CF<sub>3</sub>-Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation.
- Authors
Cotman, Andrej Emanuel; Cahard, Dominique; Mohar, Barbara
- Abstract
CF3-substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3-substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction.
- Subjects
GLYCOL synthesis; FLUOROFORM; RUTHENIUM catalysts; TRANSFER hydrogenation; ASYMMETRIC synthesis; STEREOSELECTIVE reactions; FORMIC acid
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 17, p5380
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201600812