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- Title
Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature.
- Authors
Al ‐ Shuaeeb, Riyadh Ahmed Atto; Kolodych, Sergii; Koniev, Oleksandr; Delacroix, SébastiEN; Erb, Stéphane; Nicolaÿ, Stéphanie; Cintrat, Jean ‐ Christophe; Brion, Jean ‐ Daniel; Cianférani, Sarah; Alami, Mouâd; Wagner, Alain; Messaoudi, Samir
- Abstract
The third generation of aminobiphenyl palladacycle pre-catalyst 'G3-Xantphos' enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.
- Subjects
AMINOBIPHENYL compounds; CYSTEINE; BIOCONJUGATES; METABOLIC conjugation; CHEMOSELECTIVITY
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 32, p11365
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201602277