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- Title
OPG is Required for the Postnatal Maintenance of Condylar Cartilage.
- Authors
Chen, Danying; Liu, Yi; Liu, Zongxiang; Wang, Penglai
- Abstract
Osteoprotegerin (OPG) is one of the protective factors of bony tissue. However, the function of OPG in cartilage tissues remains elusive. The aim of this study is to explore the function of OPG in the postnatal maintenance and the occurring of osteoarthritis (OA) of temporomandibular joint (TMJ) in the rodent models. We found that OPG expressed in the hypertrophic layer of the condylar cartilage and upregulated in the hyperocclusion-induced-TMJ-trauma rat. In the absence of OPG, the cartilage degradation occurred prior to that in WT mice, and the 3-month-old OPG-Knockout (OPG-KO) condyle showed decreased chondrocyte proliferation and increased chondrocyte apoptosis, whereas the number of chondroclasts was comparable to WT condyle. The isolated chondrocytes from the OPG-KO mice also showed impaired survival and promoted chondrogenic differentiation. Furthermore, the hyperocclusion model deteriorated TMJ degradation in the OPG-KO mice. OPG plays a protective role in the condylar chondrocytes' survival, and it is required for the postnatal maintenance of TMJ.
- Subjects
CARTILAGE; MANDIBULAR condyle; ENDOCHONDRAL ossification; TEMPOROMANDIBULAR joint; OSTEOPROTEGERIN; CARTILAGE cells; ANIMAL experimentation; ARTICULAR cartilage; BIOLOGICAL models; CELL differentiation; CELL receptors; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; MICE; OSTEOARTHRITIS; RESEARCH; EVALUATION research
- Publication
Calcified Tissue International, 2019, Vol 104, Issue 4, p461
- ISSN
0171-967X
- Publication type
journal article
- DOI
10.1007/s00223-018-00510-z