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- Title
Robust trend tests with application to toxicology.
- Authors
Neuhäuser, Markus; Seidel, Dirk; Hothorn, Ludwig A.; Urfer, Wolfgang
- Abstract
In most real data situations in the one-way design both the underlying distribution and the shape of the dose-response curve are a priori unknown. The power of a trend test strongly depends on both. However, tests which are routinely used to analyze toxicological assays must be robust. We use nonparametric tests with different scores—powerful for different distributions—and different contrasts—powerful for different shapes—and use the maximum of all test statistics as a new test statistic. Simulation results indicate that this maximum test, which is a nonparametric multiple contrast test, stabilizes the power for various shapes and distributions. The investigated tests are applied to the data of a toxicological assay.
- Subjects
DOSE-response relationship in poisons; DOSE-response relationship in biochemistry; TOXICOLOGY; MEDICINE; PHARMACOLOGY
- Publication
Environmental & Ecological Statistics, 2000, Vol 7, Issue 1, p43
- ISSN
1352-8505
- Publication type
Article
- DOI
10.1023/a:1009606812545