The sea-urchin metabolite spinochrome D ( 1) was synthesized in 58% overall yield via oxidation of 2,3-dichloronaphthazarin ( 13) into 2-hydroxy-6,7-dichloronaphthazarin ( 14), O-methylation of 14, nucleophilic substitution by MeO groups of the Cl atoms in the resulting 2-methoxy-6,7-dichloronaphthazarin ( 19), and hydrolysis of the obtained 2,3,6-trimethoxynaphthazarin ( 10).