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- Title
A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.
- Authors
Li, Yong; He, Liujun; Qin, Hongxia; Liu, Yao; Yang, Binxin; Xu, Zhigang; Yang, Donglin
- Abstract
A facile methodology for the construction of a complex heterocycle indazolo-fused quinoxalinone has been developed via an Ugi four-component reaction (U-4CR) followed by an intramolecular Ullmann reaction. The expeditious process features an operationally simple approach, time efficiency, and a broad substrate scope. Biological activity was evaluated and demonstrated that compound 6e inhibits human colon cancer cell HCT116 proliferation with an IC50 of 2.1 μM, suggesting potential applications for developing a drug lead in medicinal chemistry.
- Subjects
ANTINEOPLASTIC agents; CANCER cell proliferation; COLON cancer; PHARMACEUTICAL chemistry
- Publication
Molecules, 2024, Vol 29, Issue 2, p464
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29020464