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- Title
Risk of tuberculosis after endoscopic resection and gastrectomy in gastric cancer: nationwide population-based matched cohort study.
- Authors
Khil, Hye Sung; Choi, Sue In; Kim, Byung-Keun; Lee, Eun Joo; Lee, Sang Yeub; Kim, Ji Hyun; Jung, Won Jai
- Abstract
Background: This study aimed to investigate the association between gastrectomy and endoscopic resection for gastric cancer and the subsequent tuberculosis incidence. Methods: We conducted a nationwide matched cohort study using data from the Korea National Health Insurance Service from 2013 to 2019. We created two cohorts: patients who underwent gastrectomy and those who had endoscopic resection. Each patient was matched 1:1 with an unexposed individual based on index year, age, sex, income, and various comorbidities. The primary outcome was the incidence of tuberculosis during the follow-up period. Results: Our study comprised 90,886 gastrectomy patients and 46,759 endoscopic resection patients. The tuberculosis incidence was significantly higher in the gastrectomy group compared to its matched non-gastrectomy group (IRR 1.69, 95% CI 1.43–1.99, p <.001). In contrast, there was no significant difference in tuberculosis incidence between the endoscopic resection group and its matched non-resection group (IRR 0.95, 95% CI 0.75–1.19, p = 0.627). The Kaplan–Meier cumulative incidence also did not differ between the two groups. However, tuberculosis incidence significantly increased in the first year after endoscopic resection. Conclusion: Gastrectomy for gastric cancer is associated with a higher incidence of subsequent tuberculosis, while no significant association was observed for endoscopic resection. However, tuberculosis incidence increases significantly during the first year after endoscopic resection.
- Subjects
SOUTH Korea; STOMACH tumors; CHRONIC kidney failure; CONFIDENCE intervals; LOG-rank test; TIME; GASTRECTOMY; RISK assessment; DESCRIPTIVE statistics; KAPLAN-Meier estimator; CHI-squared test; OBSTRUCTIVE lung diseases; ENDOSCOPIC gastrointestinal surgery; DATA analysis software; LOGISTIC regression analysis; LONGITUDINAL method; PROBABILITY theory; PROPORTIONAL hazards models
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2024, Vol 38, Issue 3, p1358
- ISSN
1866-6817
- Publication type
Article
- DOI
10.1007/s00464-023-10610-z