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- Title
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
- Authors
Arnon, Tal I.; Achdout, Hagit; Levi, Ofer; Markel, Gal; Saleh, Nivin; Katz, Gil; Gazit, Roi; Gonen-Gross, Tsufit; Hanna, Jacob; Nahari, Efrat; Porgador, Angel; Honigman, Alik; Plachter, Bodo; Mevorach, Dror; Wolf, Dana G.; Mandelboim, Ofer
- Abstract
Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3?from NKp30 and, consequently, to reduced killing. Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor.
- Subjects
CELL-mediated cytotoxicity; IMMUNE system; VIRAL proteins; CELLULAR mechanics; KILLER cells; IMMUNOCOMPETENT cells
- Publication
Nature Immunology, 2005, Vol 6, Issue 5, p515
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1190