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HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.941839
By:
- Kanchan, Kanika;
- Shankar, Gautam;
- Huffaker, Michelle F.;
- Bahnson, Henry T.;
- Chinthrajah, R. Sharon;
- Sanda, Srinath;
- Manohar, Monali;
- Hua Ling;
- Paschall, Justin E.;
- Toit, George Du;
- Ruczinski, Ingo;
- Togias, Alkis;
- Lack, Gideon;
- Nadeau, Kari C.;
- Jones, Stacie M.;
- Nepom, Gerald T.;
- Mathias, Rasika A.
Publication type:
Article
Synergistic targeting of immunologic pathways to empower durable tolerance therapies.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.962177
By:
- Nepom, Gerald T.
Publication type:
Article
Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.
Published in:
International Immunology, 2001, v. 13, n. 6, p. 799, doi. 10.1093/intimm/13.6.799
By:
- Novak, Erik J.;
- Masewicz, Susan A.;
- Liu, Andrew W.;
- Lernmark, Åke;
- Kwok, William W.;
- Nepom, Gerald T.
Publication type:
Article
Characterization of the HLA-restrictive elements of a rubella virus-specific cytotoxic T cell clone: influence of HLA-DR4β chain residue 74 polymorphism on antigenic peptide-T cell interaction.
Published in:
International Immunology, 1996, v. 8, n. 10, p. 1577, doi. 10.1093/intimm/8.10.1577
By:
- Ou, Dawei;
- Mitchell, Leslie Ann;
- Domeier, Mary Ellen;
- Tsang, Angela O.W.;
- Décarie, Diane;
- Tingle, Aubrey J.;
- Nepom, Gerald T.;
- Lacroix, Martial;
- Zrein, Maan
Publication type:
Article
HLA-DR class II associations with rubella vaccine-induced joint manifestations.
Published in:
1998
By:
- Mitchell, Leslie Ann;
- Tingle, Aubrey J.;
- MacWilliam, Laurie;
- Horne, Cathy;
- Keown, Paul;
- Gaur, Lakshmi K.;
- Nepom, Gerald T.;
- Mitchell, L A;
- Tingle, A J;
- MacWilliam, L;
- Horne, C;
- Keown, P;
- Gaur, L K;
- Nepom, G T
Publication type:
journal article
Autoreactive T Cells in a Partially Humanized Murine Model of T1D.
Published in:
Annals of the New York Academy of Sciences, 2007, v. 1103, p. 69, doi. 10.1196/annals.1394.001
By:
- GEBE, JOHN A.;
- FALK, BEN;
- UNRATH, KELLEE;
- NEPOM, GERALD T.
Publication type:
Article
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.
Published in:
Diabetologia, 2024, v. 67, n. 1, p. 27, doi. 10.1007/s00125-023-06014-2
By:
- Mathieu, Chantal;
- Wiedeman, Alice;
- Cerosaletti, Karen;
- Long, S. Alice;
- Serti, Elisavet;
- Cooney, Laura;
- Vermeiren, Joan;
- Caluwaerts, Silvia;
- Van Huynegem, Karolien;
- Steidler, Lothar;
- Blomme, Sven;
- Rottiers, Pieter;
- Nepom, Gerald T.;
- Herold, Kevan C.
Publication type:
Article
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.
Published in:
Diabetologia, 2017, v. 60, n. 1, p. 35, doi. 10.1007/s00125-016-4144-8
By:
- Bonifacio, Ezio;
- Mathieu, Chantal;
- Nepom, Gerald;
- Ziegler, Anette-G.;
- Anhalt, Henry;
- Haller, Michael;
- Harrison, Leonard;
- Hebrok, Matthias;
- Kushner, Jake;
- Norris, Jill;
- Peakman, Mark;
- Powers, Alvin;
- Todd, John;
- Atkinson, Mark
Publication type:
Article
IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan.
Published in:
Journal of Diabetes Research, 2013, p. 1, doi. 10.1155/2013/342479
By:
- Bollyky, Paul L.;
- Vernon, Robert B.;
- Falk, Ben A.;
- Preisinger, Anton;
- Gooden, Michel D.;
- Nepom, Gerald T.;
- Gebe, John A.
Publication type:
Article
Avidity-Dependent Programming of Autoreactive T Cells in T1D.
Published in:
PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0098074
By:
- Durinovic-Belló, Ivana;
- Gersuk, Vivian H.;
- Ni, Chester;
- Wu, Rebecca;
- Thorpe, Jerill;
- Jospe, Nicholas;
- Sanda, Srinath;
- Greenbaum, Carla J.;
- Nepom, Gerald T.
Publication type:
Article
Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0054712
By:
- Sarikonda, Ghanashyam;
- Sachithanantham, Sowbarnika;
- Manenkova, Yulia;
- Kupfer, Tinalyn;
- Posgai, Amanda;
- Wasserfall, Clive;
- Bernstein, Philip;
- Straub, Laura;
- Pagni, Philippe P.;
- Schneider, Darius;
- Calvo, Teresa Rodriguez;
- Coulombe, Marilyne;
- Herold, Kevan;
- Gill, Ronald G.;
- Atkinson, Mark;
- Nepom, Gerald;
- Ehlers, Mario;
- Staeva, Teodora;
- Garren, Hideki;
- Steinman, Lawrence
Publication type:
Article
Investigating the Role of T-Cell Avidity and Killing Efficacy in Relation to Type 1 Diabetes Prediction.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0014796
By:
- Khadra, Anmar;
- Pietropaolo, Massimo;
- Nepom, Gerald T.;
- Sherman, Arthur
Publication type:
Article
The Toll-Like Receptor Signaling Molecule Myd88 Contributes to Pancreatic Beta-Cell Homeostasis in Response to Injury.
Published in:
PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005063
By:
- Bollyky, Paul L.;
- Bice, Jeffrey B.;
- Sweet, Ian R.;
- Falk, Ben A.;
- Gebe, John A.;
- Clark, April E.;
- Gersuk, Vivian H.;
- Aderem, Alan;
- Hawn, Thomas R.;
- Nepom, Gerald T.
Publication type:
Article
Detection of CD4+ Autoreactive T Cells in T1D Using HLA Class II Tetramers.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 1005, n. 1, p. 82, doi. 10.1196/annals.1288.009
By:
- REIJONEN, HELENA;
- KWOK, WILLIAM W.;
- NEPOM, GERALD T.
Publication type:
Article
HLA Class II Variants: Structural Studies and Disease Associationsa.
Published in:
Annals of the New York Academy of Sciences, 1986, v. 475, n. 1, p. 1, doi. 10.1111/j.1749-6632.1986.tb20851.x
By:
- NEPOM, GERALD T.
Publication type:
Article
The Immune Tolerance Network at 10 years: tolerance research at the bedside.
Published in:
2010
By:
- Bluestone, Jeffrey A.;
- Auchincloss, Hugh;
- Nepom, Gerald T.;
- Rotrosen, Daniel;
- St. Clair, E. William;
- Turka, Laurence A.
Publication type:
journal article
Mucosal matters.
Published in:
Nature Reviews Immunology, 2008, v. 8, n. 6, p. 409, doi. 10.1038/nri2342
By:
- Nepom, Gerald T.
Publication type:
Article
Challenges in the pursuit of immune tolerance.
Published in:
Immunological Reviews, 2011, v. 241, n. 1, p. 49, doi. 10.1111/j.1600-065X.2011.01003.x
By:
- Nepom, Gerald T.;
- St. Clair, E. William;
- Turka, Laurence A.
Publication type:
Article
Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study.
Published in:
2002
By:
- Lagasse, James M.;
- Brantley, Michael S.;
- Hagopian, William A.;
- Leech, Nicola J.;
- Rowe, Rachel E.;
- Monks, Stephanie;
- Palmer, Jerry P.;
- Nepom, Gerald T.;
- McCulloch, David K.;
- Washingtno State Diabetes Prediction Study
Publication type:
journal article
Immunogenetic Analysis Suggests Different Pathogenesis for Obese and Lean African-Americans With Diabetic Ketoacidosis.
Published in:
Diabetes Care, 1999, v. 22, n. 9, p. 1517, doi. 10.2337/diacare.22.9.1517
By:
- Umpierrez, Guillermo E.;
- Woo, Wayne;
- Hagopian, William A.;
- Isaacs, Scott D.;
- Palmer, Jerry P.;
- Gaur, Lakshmi K.;
- Nepom, Gerald M.;
- Clark, W. Scott;
- Mixon, Peggy S.;
- Kitabchi, Abbas E.
Publication type:
Article
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.
Published in:
2020
By:
- Wiedeman, Alice E.;
- Muir, Virginia S.;
- Rosasco, Mario G.;
- DeBerg, Hannah A.;
- Presnell, Scott;
- Haas, Bertrand;
- Dufort, Matthew J.;
- Speake, Cate;
- Greenbaum, Carla J.;
- Serti, Elisavet;
- Nepom, Gerald T.;
- Blahnik, Gabriele;
- Kus, Anna M.;
- James, Eddie A.;
- Linsley, Peter S.;
- Long, S. Alice
Publication type:
journal article
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.
Published in:
Journal of Clinical Investigation, 2020, v. 130, n. 1, p. 480, doi. 10.1172/JCI126595
By:
- Wiedeman, Alice E.;
- Muir, Virginia S.;
- Rosasco, Mario G.;
- DeBerg, Hannah A.;
- Presnell, Scott;
- Haas, Bertrand;
- Dufort, Matthew J.;
- Speake, Cate;
- Greenbaum, Carla J.;
- Serti, Elisavet;
- Nepom, Gerald T.;
- Blahnik, Gabriele;
- Kus, Anna M.;
- James, Eddie A.;
- Linsley, Peter S.;
- Long, S. Alice
Publication type:
Article
Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8+ T cells beneficial in type 1 diabetes.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06456-3
By:
- Witkop, Erin M.;
- Diggins, Kirsten;
- Wiedeman, Alice;
- Serti, Elisavet;
- Nepom, Gerald;
- Gersuk, Vivian H.;
- Fuchs, Bryce;
- Long, S. Alice;
- Linsley, Peter S.
Publication type:
Article
Animal models of human type 1 diabetes.
Published in:
Nature Immunology, 2009, v. 10, n. 2, p. 129, doi. 10.1038/ni0209-129
By:
- von Herrath, Matthias;
- Nepom, Gerald T
Publication type:
Article
Class II peptide multimers: promise for type 1A diabetes?
Published in:
Nature Immunology, 2002, v. 3, n. 4, p. 344, doi. 10.1038/ni0402-344
By:
- Eisenbarth, George S.;
- Nepom, Gerald T.
Publication type:
Article
Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.
Published in:
Science Immunology, 2016, v. 1, n. 5, p. 1, doi. 10.1126/sciimmunol.aai7793
By:
- Long, S. Alice;
- Thorpe, Jerill;
- DeBerg, Hannah A.;
- Gersuk, Vivian;
- Eddy, James A.;
- Harris,3, Kristina M.;
- Ehlers, Mario;
- Herold, Kevan C.;
- Nepom, Gerald T.;
- Linsley, Peter S.
Publication type:
Article
Approaches to Establishing Tolerance in Immune Mediated Diseases.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.744804
By:
- Huffaker, Michelle F.;
- Sanda, Srinath;
- Chandran, Sindhu;
- Chung, Sharon A.;
- St. Clair, E. William;
- Nepom, Gerald T.;
- Smilek, Dawn E.
Publication type:
Article
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.
Published in:
Science Translational Medicine, 2015, v. 7, n. 287, p. 1, doi. 10.1126/scitranslmed.aaa8038
By:
- Yonghao Cao;
- Goods, Brittany A.;
- Raddassi, Khadir;
- Nepom, Gerald T.;
- Kwok, William W.;
- Love, J. Christopher;
- Hafler, David A.
Publication type:
Article
Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box.
Published in:
Immunologic Research, 1993, v. 12, n. 4, p. 317, doi. 10.1007/BF02935505
By:
- Sukiennicki, Teresa;
- Shewey, Linda;
- Nepom, Gerald
Publication type:
Article
Structural variation among major histocompatibility complex class-II genes which predispose to autoimmunity.
Published in:
Immunologic Research, 1989, v. 8, n. 1, p. 16, doi. 10.1007/BF02918553
By:
- Nepom, Gerald
Publication type:
Article
Identification of Novel HLA-A*0201--Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives.
Published in:
Diabetes, 2006, v. 55, n. 11, p. 3061, doi. 10.2337/db06-0066
By:
- Standifer, Nathan E.;
- Qin Ouyang;
- Panagiotopoulos, Constadina;
- Verchere, C. Bruce;
- Rusung Tan;
- Greenbaum, Carla J.;
- Pihoker, Catherine;
- Nepom, Gerald T.
Publication type:
Article
Recognition of HLA Class I-Restricted β-Cell Epitopes in Type 1 Diabetes.
Published in:
Diabetes, 2006, v. 55, n. 11, p. 3068, doi. 10.2337/db06-0065
By:
- Qin Ouyang;
- Standifer, Nathan E.;
- Huilian Qin;
- Gottlieb, Peter;
- Verchere, C. Bruce;
- Nepom, Gerald T.;
- Rusung Tan;
- Panagiotopoulos, Constadina
Publication type:
Article
Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes.
Published in:
Diabetes, 2006, v. 55, n. 9, p. 2588, doi. 10.2337/db05-1378
By:
- Seyfert-Margolis, Vicki;
- Gisler, Trang D.;
- Asare, Adam L.;
- Wang, Richard S.;
- Dosch, H. Michael;
- Brooks-Worrell, Barbara;
- Eisenbarth, George S.;
- Palmer, Jerry P.;
- Greenbaum, Carla J.;
- Gitelman, Stephen E.;
- Nepom, Gerald T.;
- Bluestone, Jeffrey A.;
- Herold, Kevan C.
Publication type:
Article
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
Published in:
2004
By:
- Reijonen, Helena;
- Mallone, Roberto;
- Heninger, Anne-Kristin;
- Laughlin, Elsa M.;
- Kochik, Sharon A.;
- Falk, Ben;
- Kwok, William W.;
- Greenbaum, Carla;
- Nepom, Gerald T.
Publication type:
journal article
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
Published in:
2004
By:
- Mallone, Roberto;
- Kochik, Sharon A.;
- Laughlin, Elsa M.;
- Gersuk, Vivian H.;
- Reijonen, Helena;
- Kwok, William W.;
- Nepom, Gerald T.
Publication type:
journal article
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
Published in:
2002
By:
- Reijonen, Helena;
- Novak, Erik J.;
- Kochik, Sharon;
- Heninger, Anne;
- Liu, Andrew W.;
- Kwok, William W.;
- Nepom, Gerald T.
Publication type:
journal article
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.
Published in:
2000
By:
- Reijonen, Helena;
- Daniels, Terri L.;
- Lernmark, Ake;
- Nepom, Gerald T.;
- Reijonen, H;
- Daniels, T L;
- Lernmark, A;
- Nepom, G T
Publication type:
journal article
Molecular basis for HLA-DQ associations with IDDM.
Published in:
1998
By:
- Nepom, Gerald T.;
- Kwok, William W.;
- Nepom, G T;
- Kwok, W W
Publication type:
journal article
Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome.
Published in:
1995
By:
- Uchigata, Yasuko;
- Tokunaga, Katsushi;
- Nepom, Gerald;
- Bannai, Makoto;
- Kuwata, Shoji;
- Dozio, Nicoletta;
- Benson, Edward A.;
- Ronningen, Kjersti S.;
- Spinas, Glatgen A.;
- Tadokoro, Kenji;
- Hirata, Yukimasa;
- Juji, Takeo;
- Omori, Yasue;
- Uchigata, Y;
- Tokunaga, K;
- Nepom, G;
- Bannai, M;
- Kuwata, S;
- Dozio, N;
- Benson, E A
Publication type:
journal article
The Prevention of IDDM.
Published in:
Diabetes, 1995, v. 44, n. 7, p. 859
By:
- Gladstone, Paul;
- Nepom, Gerald T.
Publication type:
Article
High genetic risk for IDDM in the Pacific Northwest. First report from the Washington State Diabetes Prediction Study.
Published in:
1994
By:
- Rowe, Rachel E.;
- Leech, Nicola J.;
- Nepom, Gerald T.;
- McCulloch, David K.;
- Rowe, R E;
- Leech, N J;
- Nepom, G T;
- McCulloch, D K
Publication type:
journal article
A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM.
Published in:
Diabetes, 1990, v. 39, n. 10, p. 1153, doi. 10.2337/diab.39.10.1153
By:
- Nepom, Gerald T.
Publication type:
Article
Nonprogression of Subclinical β-Cell Dysfunction Among First-Degree Relatives of IDDM Patients.
Published in:
Diabetes, 1990, v. 39, n. 5, p. 549, doi. 10.2337/diab.39.5.549
By:
- McCulloch, David K.;
- Klaff, Leslie J.;
- Kahn, Steven E.;
- Schoenfeld, Steven L.;
- Greenbaum, Carla J.;
- Mauseth, Richard S.;
- Benson, Edward A.;
- Nepom, Gerald T.;
- Shewey, Linda;
- Palmer, Jerry P.
Publication type:
Article
HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM.
Published in:
Diabetes, 1990, v. 39, n. 1, p. 96, doi. 10.2337/diacare.39.1.96
By:
- Erlich, Henry A.;
- Bugawan, Teodorica L.;
- Scharf, Stephen;
- Nepom, Gerald T.;
- Tait, Brian;
- Griffith, Robert L.
Publication type:
Article
Transcomplementation of HLA Genes in IDDM.
Published in:
Diabetes, 1987, v. 36, n. 1, p. 114, doi. 10.2337/diab.36.1.114
By:
- Nepom, Barbara S.;
- Schwarz, David;
- Palmer, Jerry P.;
- Nepom, Gerald T.
Publication type:
Article
Genetically modified human CD4+ T cells can be evaluated in vivo without lethal graft-versus-host disease.
Published in:
Immunology, 2016, v. 148, n. 4, p. 339, doi. 10.1111/imm.12613
By:
- Ali, Riyasat;
- Babad, Jeffrey;
- Follenzi, Antonia;
- Gebe, John A.;
- Brehm, Michael A.;
- Nepom, Gerald T.;
- Shultz, Leonard D.;
- Greiner, Dale L.;
- DiLorenzo, Teresa P.
Publication type:
Article
Investigating the HLA component in rheumatoid arthritis: An additive (dominant) mode of inheritance is rejected, a recessive mode is preferred.
Published in:
Genetic Epidemiology, 1991, v. 8, n. 3, p. 153, doi. 10.1002/gepi.1370080303
By:
- Rigby, Alan S.;
- Silman, Alan J.;
- Voelm, Lianne;
- Gregory, Julie C.;
- Ollier, William E. R.;
- Khan, Muhammad A.;
- Nepom, Gerald T.;
- Thomson, Glenys;
- Vogler, G. P.
Publication type:
Article
HLA class II typing using oligonucleotide probes.
Published in:
Genetic Epidemiology, 1989, v. 6, n. 1, p. 27, doi. 10.1002/gepi.1370060107
By:
- Robinson, David M.;
- Holbeck, Susan;
- Seyfried, Christine;
- Byers, Patricia;
- Palmer, Jerry;
- Nepom, Gerald T.
Publication type:
Article
HLA DQβ3.2 identifies subtypes of DR4 + haplotypes permissive for IDDM.
Published in:
Genetic Epidemiology, 1989, v. 6, n. 1, p. 149, doi. 10.1002/gepi.1370060128
By:
- Robinson, David M.;
- Holbeck, Susan;
- Palmer, Jerry;
- Nepom, Gerald T.
Publication type:
Article
Remodeling rodent models to mimic human type 1 diabetes.
Published in:
European Journal of Immunology, 2009, v. 39, n. 8, p. 2049, doi. 10.1002/eji.200939429
By:
- von Herrath, Matthias;
- Nepom, Gerald T.
Publication type:
Article

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