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- Title
IMUNOSNI ODGOVORI KOŽE USLIJED LEISHMANIA SPP. INVAZIJE (2).
- Authors
Štimac, Iva; Martinković, Franjo
- Abstract
On stimulation, a variety of immune cells are rapidly recruited to the skin from the blood or lymphatic tissue, leading to the resulting immune responses. Depending on the nature of the trigger, different immune cells may be recruited in response to distinct pathogens. In addition, the sequence of events is often critical for disease outcome or pathogen control. After transmission of Leishmania parasites by sandflies, disease manifestation of the infection requires mechanisms which allow the parasites to replicate in the mammalian host and to resist, at least initially, its innate and adaptive immune response. Likewise, lifelong persistence of Leishmania parasites, as it occurs even in cases of clinical healing of the infection, points to the existence of strategies which enable the parasite to partially circumvent the protective adaptive immune response of the host. Changes in signaling pathways and cell phenotype, as well as the increased production of a series of pro-inflammatory and anti-inflammatory mediators, may contribute in a systematic way to the negative modulation of the immune response in the initial moments of infection. These mechanisms emerged because of a long parasite - host co-evolutionary process. Recent advances in imaging technologies as well as studies combining immunological and genetic manipulations have allowed for a better understanding of the interactions between Leishmania and its mammalian hosts. Further investigation of innate immune cells and Leishmania can lead to a better understanding of the infectious process and to better vaccines for leishmaniasis.
- Subjects
LYMPHOID tissue; IMMUNOREGULATION; LEISHMANIASIS; IMMUNE response; SAND flies; PATTERN perception receptors
- Publication
Veterinaria, 2022, Vol 71, Issue 3, p373
- ISSN
0372-6827
- Publication type
Article
- DOI
10.51607/22331360.2022.71.3.373