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- Title
Testicular function among testicular cancer survivors treated with cisplatin-based chemotherapy.
- Authors
Namekawa, Takeshi; Imamoto, Takashi; Kato, Mayuko; Sazuka, Tomokazu; Fuse, Miki; Sakamoto, Shinichi; Kawamura, Koji; Ichikawa, Tomohiko
- Abstract
Purpose: The aim of our study was to identify the clinical predictors of spermatogenesis recovery in testicular cancer (TC) patients after chemotherapy and to determine the recuperation period for spermatogenesis. Methods: Patients treated for TC from January 1982 to November 2001 at Chiba University Hospital were retrospectively assessed. Thirty-five patients who met the following criteria were examined-(i) underwent both high orchiectomy and cisplatin-based chemotherapy; (ii) had semen analyses and hormonal measurements; and (iii) were alive with no evidence of disease. Clinical variables associated with normalization of spermatogenesis after chemotherapy were examined. Time to recover normospermia was also evaluated using Kaplan-Meier analysis. Results: The observation period was 13.3 ± 5.6 years. Reappearance of sperm was confirmed in 85.7 % of patients, and 54.3 % of patients recovered normospermia. Age at diagnosis <25 years ( p = 0.0057), number of chemotherapy cycles <4 cycles ( p = 0.0042), and follicle-stimulating hormone at the end of chemotherapy <18 mIU/ml ( p = 0.0220) were independent factors related to post-chemotherapy normalization of semen findings. The median (95 % CI) time to recover normospermia was 40 (range 22-96) months. Conclusions: These findings help to predict whether spermatogenesis will recover and its timing. They may also help clinicians identify and manage TC patients at a higher risk of prolonged azoospermia after chemotherapy.
- Subjects
TESTICULAR cancer; CANCER chemotherapy; SPERMATOGENESIS; PATIENTS
- Publication
Reproductive Medicine & Biology, 2016, Vol 15, Issue 3, p175
- ISSN
1445-5781
- Publication type
Article
- DOI
10.1007/s12522-015-0232-6