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- Title
Modelos murinos para el estudio de la diabetes tipo 2: una revisión sistemática.
- Authors
Martí, Amelia; Tapiz, Cristina
- Abstract
In recent years, there have been an increasing number of studies focusing on diabetes mellitus, its pathophysiology, complications and treatment. Among the different types, type 2 diabetes mellitus (T2DM) is the most common. Its manifestations include insulin resistance and subsequent ß cell secretory dysfunction, and its etiology comprises both genetic and lifestyle factors. Thus, this systematic review aims to examine different animal models of T2DM in order to understand the factors that may influence its development and complications, and thus gain new information about its management and treatment in humans. In short, the utility of animal models is based on the fact that they manifest different aspects of human T2DM, but none reproduces it completely.
- Subjects
GENETICS of type 2 diabetes; TYPE 2 diabetes risk factors; TYPE 2 diabetes treatment; TYPE 2 diabetes complications; ANIMAL experimentation; BIOLOGICAL models; INSULIN resistance; TYPE 2 diabetes; RODENTS; SYSTEMATIC reviews; SEDENTARY lifestyles
- Publication
Revista de la ALAD, 2019, Vol 9, Issue 4, p165
- ISSN
2248-6518
- Publication type
Article
- DOI
10.24875/ALAD.19000382